VDAC3

This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Description

Voltage dependent anion channel 3

Tissue specificity

Group enriched (heart muscle, skeletal muscle, tongue)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (42391624 - 42405937)

Ensembl ID

ENSG00000078668  (ver. 103.38)

Orthologs

Mouse Vdac3: ENSMUSG00000008892

UniProt

Q9Y277

neXtProt

NX_Q9Y277

Human splice variants
Mouse splice variants

Protein structure