Tissue expression
Cell line expression

NCF4

gene product
p40phox, SH3PXD4 
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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541 antibodies from 38 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
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GeneTex
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Abgent
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Proteintech Group
2 antibodies
OriGene
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Cusabio Biotech Co., Ltd
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Antibodies.com
1 antibody
Everest Biotech
1 antibody
NSJ Bioreagents
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
Arigo
1 antibody
Santa Cruz Biotechnology
1 antibody
Boster Biological Technology
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ProSci
2 antibodies
RabMAbs
2 antibodies
Cell Signaling Technology, Inc
1 antibody
Creative Diagnostics
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Atlas Antibodies
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MyBioSource
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Leading Biology
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Abbexa
6 antibodies
RayBiotech, Inc.
2 antibodies
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13 antibodies
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MilliporeSigma / Merck KGaA
5 antibodies
EMD Millipore
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