NCF4

gene product
p40phox, SH3PXD4
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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459 antibodies from 35 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
149 antibodies
Novus Biologicals
25 antibodies
Biorbyt
22 antibodies
Aviva Systems Biology
7 antibodies
NovoPro Bioscience Inc.
5 antibodies
Abnova Corporation
7 antibodies
GeneTex
4 antibodies
Abgent
4 antibodies
Invitrogen Antibodies
8 antibodies
Bioworld Technology, Inc
2 antibodies
Acris Antibodies GmbH
9 antibodies
Affinity Biosciences
4 antibodies
St John's Laboratory
5 antibodies
LifeSpan BioSciences, Inc.
72 antibodies
Antibodies.com
1 antibody
Everest Biotech
1 antibody
NSJ Bioreagents
1 antibody
OriGene
22 antibodies
Arigo
1 antibody
Santa Cruz Biotechnology
1 antibody
ProSci
2 antibodies
RabMAbs
2 antibodies
Cell Signaling Technology, Inc
1 antibody
Creative Biolabs
14 antibodies
Creative Diagnostics
5 antibodies
Proteintech Group
1 antibody
Atlas Antibodies
2 antibodies
MyBioSource
5 antibodies
Boster Biological Technology
2 antibodies
RayBiotech, Inc.
2 antibodies
United States Biological
39 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
EMD Millipore
3 antibodies
Sigma-Aldrich
5 antibodies