TRIM22

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Description

Tripartite motif containing 22

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Golgi apparatus

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (5689697 - 5737089)

Ensembl ID

ENSG00000132274  (ver. 103.38)

Orthologs

Mouse Trim75: ENSMUSG00000071089

UniProt

Q8IYM9

neXtProt

NX_Q8IYM9

Human splice variants
Mouse splice variants

Protein structure