CDH17

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Description

Cadherin 17

Tissue specificity

Tissue enriched (intestine)

Subcell location

Nucleoplasm, Cell Junctions

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8:q22.1 (94127162 - 94217303)

Ensembl ID

ENSG00000079112  (ver. 103.38)

Orthologs

Mouse Cdh17: ENSMUSG00000028217

UniProt

Q12864

neXtProt

NX_Q12864

Human splice variants
Mouse splice variants