Tissue expression
Cell line expression
Protein structure
BIN1
Bridging integrator 1AMPH2, AMPHL, SH3P9
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]
Top validated antibodies |
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Proteintech Group | 14647-1-AP | 11 references | Polyclonal |
WB
EL
IP
IHC |
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Atlas Antibodies | HPA003894 | 1 references | Polyclonal |
WB
ICC
IHC
|
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Invitrogen Antibodies | PA5-34687 | 1 references | Polyclonal |
WB
ICC
IHC
OA |
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NSJ Bioreagents | RQ6602 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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antibodies-online | ABIN1043736 | 2 references | Monoclonal |
WB
EL
IP
IHC
FC
|
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