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Protein structure
API5
Apoptosis inhibitor 5AAC-11, AAC11, API5L1
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Top validated antibodies |
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| antibodies-online |  ABIN394905 |
5 references | Monoclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | H00008539-M01 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| Abnova Corporation | H00008539-M01 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| Proteintech Group | 25689-1-AP |
3 references | Polyclonal |
WB
EL
ICC
IHC
|
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| LSBio | LS-C353072 |
Polyclonal |
WB
IP
IHC
|
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