BTC

This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015]

Description

Betacellulin

Tissue specificity

Tissue enhanced (intestine)

Predicted location

Intracellular, Membrane, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Chromosome

4 (74744759 - 74794523)

Ensembl ID

ENSG00000174808  (ver. 103.38)

Orthologs

Mouse Btc: ENSMUSG00000082361

UniProt

P35070

neXtProt

NX_P35070

Human splice variants
Mouse splice variants

Protein structure