CCM2

gene product
C7orf22, MGC4607, OSM
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
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318 antibodies from 28 providers.

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Antibody
Proteintech Group
1 antibody
Novus Biologicals
30 antibodies
OriGene
45 antibodies
Atlas Antibodies
3 antibodies
LifeSpan BioSciences, Inc.
42 antibodies
antibodies-online
108 antibodies
Invitrogen Antibodies
8 antibodies
ReliaTech GmbH
2 antibodies
Biorbyt
10 antibodies
Acris Antibodies GmbH
6 antibodies
Abnova Corporation
6 antibodies
NovoPro Bioscience Inc.
2 antibodies
GeneTex
3 antibodies
St John's Laboratory
2 antibodies
Antibodies.com
1 antibody
Bioworld Technology, Inc
1 antibody
Everest Biotech
1 antibody
NSJ Bioreagents
1 antibody
Aviva Systems Biology
2 antibodies
Arigo
1 antibody
Creative Biolabs
17 antibodies
Affinity Biosciences
1 antibody
ProSci
1 antibody
MyBioSource
5 antibodies
Sigma-Aldrich
4 antibodies
Abbexa
2 antibodies
United States Biological
12 antibodies
Leading Biology
1 antibody