FDFT1

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]

Description

farnesyl-diphosphate farnesyltransferase 1

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

8:p23.1 (11795573 - 11839309)

Ensembl ID

ENSG00000079459  (ver. 84.38)

Orthologs

Mouse Fdft1: ENSMUSG00000021273

UniProt

P37268

neXtProt

NX_P37268

Human splice variants
Mouse splice variants