BMP7

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]

Description

bone morphogenetic protein 7

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

20:q13.31 (57168753 - 57266641)

Ensembl ID

ENSG00000101144  (ver. 99.38)

Orthologs

Mouse Bmp7: ENSMUSG00000008999

UniProt

P18075

neXtProt

NX_P18075

Human splice variants
Mouse splice variants