TLN1

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

Description

Talin 1

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Focal adhesion sites, Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (35696948 - 35732195)

Ensembl ID

ENSG00000137076  (ver. 103.38)

Orthologs

Mouse Tln1: ENSMUSG00000028465

UniProt

Q9Y490

neXtProt

NX_Q9Y490

Human splice variants
Mouse splice variants

Protein structure