PDLIM3

The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]

Description

PDZ and LIM domain 3

Tissue specificity

Group enriched (skeletal muscle, tongue)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (185500660 - 185535507)

Ensembl ID

ENSG00000154553  (ver. 103.38)

Orthologs

Mouse Pdlim3: ENSMUSG00000031636

UniProt

Q53GG5

neXtProt

NX_Q53GG5

Human splice variants
Mouse splice variants

Protein structure