AGR2

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]

Description

Anterior gradient 2, protein disulphide isomerase family member

Tissue specificity

Tissue enhanced (cervix, intestine, stomach)

Subcell location

Endoplasmic reticulum

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (16791811 - 16833433)

Ensembl ID

ENSG00000106541  (ver. 103.38)

Orthologs

Mouse Agr2: ENSMUSG00000020581

UniProt

O95994

neXtProt

NX_O95994

Human splice variants
Mouse splice variants

Protein structure