APAF1

gene product
APAF-1, CED4
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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674 antibodies from 41 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
10 antibodies
antibodies-online
269 antibodies
Enzo Life Sciences
5 antibodies
Boster Biological Technology
3 antibodies
NovoPro Bioscience Inc.
1 antibody
Abnova Corporation
17 antibodies
Proteintech Group
1 antibody
LifeSpan BioSciences, Inc.
108 antibodies
Biorbyt
36 antibodies
OriGene
20 antibodies
Affinity Biosciences
5 antibodies
Atlas Antibodies
1 antibody
Invitrogen Antibodies
8 antibodies
Acris Antibodies GmbH
25 antibodies
Cell Signaling Technology, Inc
3 antibodies
R&D Systems
1 antibody
Abgent
8 antibodies
ProSci
9 antibodies
Aviva Systems Biology
6 antibodies
GeneTex
7 antibodies
Arigo
5 antibodies
NSJ Bioreagents
2 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
Sigma-Aldrich
5 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
St John's Laboratory
2 antibodies
Creative Biolabs
14 antibodies
EMD Millipore
5 antibodies
RabMAbs
2 antibodies
Abbiotec
2 antibodies
MyBioSource
15 antibodies
Bioworld Technology, Inc
1 antibody
Spring Bioscience
4 antibodies
RayBiotech, Inc.
3 antibodies
GenWay
4 antibodies
Abiocode, Inc.
1 antibody
United States Biological
29 antibodies
Creative Diagnostics
4 antibodies
Abbexa
3 antibodies
Exalpha Biologicals, Inc.
2 antibodies