CALD1

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Description

Caldesmon 1

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Actin filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (134744252 - 134970729)

Ensembl ID

ENSG00000122786  (ver. 103.38)

Orthologs

Mouse Cald1: ENSMUSG00000029761

UniProt

Q05682

neXtProt

NX_Q05682

Human splice variants
Mouse splice variants

Protein structure