TRAF5

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Description

TNF receptor associated factor 5

Tissue specificity

Low tissue specificity

Subcell location

Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (211326615 - 211374946)

Ensembl ID

ENSG00000082512  (ver. 103.38)

Orthologs

Mouse Traf5: ENSMUSG00000026637

UniProt

O00463

neXtProt

NX_O00463

Human splice variants
Mouse splice variants

Protein structure