P4HA3

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Description

Prolyl 4-hydroxylase subunit alpha 3

Tissue specificity

Tissue enhanced (smooth muscle)

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11 (74235801 - 74311640)

Ensembl ID

ENSG00000149380  (ver. 103.38)

Orthologs

Mouse P4ha3: ENSMUSG00000051048

UniProt

Q7Z4N8

neXtProt

NX_Q7Z4N8

Human splice variants
Mouse splice variants

Protein structure