Tissue expressionAmygdalaBasal gangliaCerebellumCerebral cortexChoroid plexusHippocampal formationHypothalamusMedulla oblongataMidbrainOlfactory bulbPonsSpinal cordThalamusWhite matterRetinaAdrenal glandParathyroid glandPituitary glandThyroid glandLungEsophagusSalivary glandTongueColonDuodenumRectumSmall intestineStomachGallbladderLiverPancreasKidneyUrinary bladderEpididymisProstateSeminal vesicleTestisBreastCervixEndometriumFallopian tubeOvaryPlacentaVaginaHeart muscleSkeletal muscleSmooth muscleAdipose tissueSkinAppendixBone marrowLymph nodeSpleenThymusTonsil02004006008001,0001,200
Cell line expressionAF22GAMGSH-SY5YU-138 MGU-251 MGU-87 MGHTCEpiHTERT-RPE1OE19CACO-2Hep G2CAPAN-2HEK 293NTERA-2RPTEC TERT1RT4PC-3SuSaA-431HaCaTSK-MEL-30WM-115A549HBEC3-KTSCLC-21HAN3-CABEWOEFO-21HeLaHTERT-HME1MCF7SiHaSK-BR-3T-47dHUVEC TERT2TIMEHSkMCASC diffASC TERT1BJBJ hTERT+BJ hTERT+ SV40 Large T+BJ hTERT+ SV40 Large T+ RasG12VFHDF/TERT166HBF TERT88HHSteCLHCN-M2RH-30U-2 OSU-2197DaudiHDLM-2HTEC/SVTERT24-BJURKATKarpas-707MOLT-4REHRPMI-8226U-266/70U-266/84U-698HAP1HELHL-60HMC-1K-562NB-4THP-1U-937050100150200250300350
Protein structure

CPS1

Carbamoyl-phosphate synthase 1
 
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation. [provided by RefSeq, May 2010]
More gene data

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                        514 antibodies from 34 providers.

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                        45 antibodies
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                        4 antibodies
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                        13 antibodies
                        OriGene
                        5 antibodies
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                        2 antibodies
                        HUABIO Research
                        1 antibody
                        NovoPro Bioscience Inc.
                        5 antibodies
                        St John's Laboratory
                        3 antibodies
                        Antibodies.com
                        15 antibodies
                        FineTest Biotech
                        2 antibodies
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                        3 antibodies
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                        1 antibody
                        Aviva Systems Biology
                        3 antibodies
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                        7 antibodies
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                        4 antibodies
                        Creative Biolabs
                        15 antibodies
                        Cell Signaling Technology, Inc
                        1 antibody
                        RayBiotech, Inc.
                        1 antibody
                        United States Biological
                        34 antibodies
                        Leading Biology
                        9 antibodies
                        MilliporeSigma / Merck KGaA
                        4 antibodies
                        MyBioSource
                        3 antibodies
                        Creative Diagnostics
                        4 antibodies
                        MedChemExpress LLC
                        1 antibody