ADORA1

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Adenosine A1 receptor

Tissue specificity

Tissue enhanced (brain, testis)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

1 (203090654 - 203167405)

Ensembl ID

ENSG00000163485  (ver. 103.38)

Orthologs

Mouse Adora1: ENSMUSG00000042429

UniProt

P30542

neXtProt

NX_P30542

Human splice variants
Mouse splice variants

Protein structure