GABBR2

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence. [provided by RefSeq, Jan 2010]

Description

Gamma-aminobutyric acid type B receptor subunit 2

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

9 (98288109 - 98708935)

Ensembl ID

ENSG00000136928  (ver. 103.38)

Orthologs

Mouse Gabbr2: ENSMUSG00000039809

UniProt

O75899

neXtProt

NX_O75899

Human splice variants
Mouse splice variants

Protein structure