Tissue expression
Cell line expression
Protein structure
EPHB2
EPH receptor B2DRT, EPHT3, ERK, Hek5, Tyro5
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Top validated antibodies |
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R&D Systems | AF467 | 28 references | Polyclonal |
WB
ICC
IHC
FC |
|
Novus Biologicals | AF467 | 31 references | Polyclonal |
WB
ICC
IHC
FC |
|
Invitrogen Antibodies | PA5-14607 | 1 references | Polyclonal |
WB
ICC
IHC
OA |
|
antibodies-online | ABIN2841731 | 3 references | Polyclonal |
WB
IHC
FC
|
|
NSJ Bioreagents | RQ6049 | Polyclonal |
WB
EL
ICC
FC |
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Supportive data in Antibodypedia
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Recommended by provider