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Protein structure
PC
Pyruvate carboxylasePCB
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  16588-1-AP |
35 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| LSBio | LS-C143227 |
Polyclonal |
WB
ICC
IHC
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| Invitrogen Antibodies | 16588-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| NSJ Bioreagents | RQ8493 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | NBP1-49536 |
8 references | Polyclonal |
WB
ICC
IHC
|
|
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