HNRNPU

gene product
C1orf199, FLJ30202, FLJ37978, hnRNPU, HNRNPU-AS1, HNRPU, NCRNA00201, SAF-A
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
More gene data

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
209 antibodies from 28 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
80 antibodies
NovoPro Bioscience Inc.
2 antibodies
Novus Biologicals
7 antibodies
GeneTex
4 antibodies
Boster Biological Technology
3 antibodies
Proteintech Group
2 antibodies
Bethyl Laboratories
3 antibodies
Biorbyt
5 antibodies
Invitrogen Antibodies
4 antibodies
Atlas Antibodies
2 antibodies
Abnova Corporation
2 antibodies
LifeSpan BioSciences, Inc.
23 antibodies
Aviva Systems Biology
3 antibodies
MyBioSource
7 antibodies
OriGene
3 antibodies
Creative Diagnostics
5 antibodies
Acris Antibodies GmbH
2 antibodies
Arigo
1 antibody
Bioworld Technology, Inc
1 antibody
GenWay
1 antibody
St John's Laboratory
5 antibodies
EMD Millipore
2 antibodies
RabMAbs
1 antibody
Signalway Antibody LLC
1 antibody
United States Biological
25 antibodies
Sigma-Aldrich
2 antibodies
Abbexa
1 antibody