Tissue expression
Cell line expression
Protein structure

TSC1

TSC complex subunit 1
hamartin, KIAA0243, LAM, TSC 
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
More gene data

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1979 antibodies from 46 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
2 antibodies
Invitrogen Antibodies
42 antibodies
NSJ Bioreagents
19 antibodies
Novus Biologicals
39 antibodies
antibodies-online
436 antibodies
Biorbyt
146 antibodies
NovoPro Bioscience Inc.
25 antibodies
FineTest Biotech
1 antibody
Abnova Corporation
7 antibodies
R&D Systems
9 antibodies
Abgent
37 antibodies
Affinity Biosciences
3 antibodies
Everest Biotech
1 antibody
Boster Biological Technology
4 antibodies
OriGene
69 antibodies
Cell Signaling Technology, Inc
3 antibodies
Aviva Systems Biology
34 antibodies
St John's Laboratory
4 antibodies
Acris Antibodies GmbH
13 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
SignalChem
2 antibodies
Antibodies.com
1 antibody
GeneTex
4 antibodies
Arigo
1 antibody
Enzo Life Sciences
1 antibody
ProSci
3 antibodies
Bethyl Laboratories
1 antibody
Creative Diagnostics
8 antibodies
MyBioSource
36 antibodies
RabMAbs
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Atlas Antibodies
1 antibody
United States Biological
382 antibodies
Creative Biolabs
31 antibodies
Abiocode, Inc.
2 antibodies
Leading Biology
36 antibodies
RayBiotech, Inc.
4 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
BioLegend
1 antibody
EMD Millipore
2 antibodies
Abbexa
20 antibodies
Abbiotec
1 antibody
GenWay
4 antibodies
Rockland Immunochemicals, Inc.
2 antibodies