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gene product
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. [provided by RefSeq, Sep 2009]
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469 antibodies from 42 providers.

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GeneTex
9 antibodies
Novus Biologicals
15 antibodies
Boster Biological Technology
4 antibodies
antibodies-online
151 antibodies
NSJ Bioreagents
3 antibodies
Abnova Corporation
5 antibodies
Biorbyt
38 antibodies
NovoPro Bioscience Inc.
6 antibodies
OriGene
9 antibodies
Invitrogen Antibodies
8 antibodies
R&D Systems
9 antibodies
Proteintech Group
1 antibody
LifeSpan BioSciences, Inc.
55 antibodies
Antibodies.com
4 antibodies
Acris Antibodies GmbH
6 antibodies
St John's Laboratory
6 antibodies
Affinity Biosciences
1 antibody
Everest Biotech
1 antibody
Aviva Systems Biology
4 antibodies
Arigo
2 antibodies
Abgent
4 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
1 antibody
ProSci
3 antibodies
Bethyl Laboratories
1 antibody
RabMAbs
7 antibodies
FabGennix
3 antibodies
Creative Biolabs
19 antibodies
MyBioSource
12 antibodies
Creative Diagnostics
5 antibodies
Abbiotec
1 antibody
BioLegend
2 antibodies
RayBiotech, Inc.
3 antibodies
Abbexa
4 antibodies
BioLegend (formerly Covance Antibody Products)
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
GenWay
1 antibody
United States Biological
38 antibodies
Sigma-Aldrich
4 antibodies
EMD Millipore
2 antibodies
Absolute Antibody
5 antibodies