Tissue expression
Cell line expression
Protein structure
CCR7
C-C motif chemokine receptor 7BLR2, CD197, CDw197, CMKBR7, EBI1
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Top validated antibodies |
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R&D Systems | ![]() |
72 references | Monoclonal |
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Novus Biologicals | ![]() |
43 references | Polyclonal |
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Boster Biological Technology | ![]() |
4 references | Monoclonal |
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GeneTex | ![]() |
2 references | Polyclonal |
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antibodies-online | ![]() |
1 references | Polyclonal |
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