XPA

This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]

Description

XPA, DNA damage recognition and repair factor

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytokinetic bridge

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (97674909 - 97697340)

Ensembl ID

ENSG00000136936  (ver. 103.38)

Orthologs

Mouse Xpa: ENSMUSG00000028329

UniProt

P23025

neXtProt

NX_P23025

Human splice variants
Mouse splice variants

Protein structure