UPRT

This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]

Description

uracil phosphoribosyltransferase homolog

Protein family

Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

X:q13.3 (75274085 - 75304600)

Ensembl ID

ENSG00000094841  (ver. 84.38)

Orthologs

Mouse Uprt: ENSMUSG00000073016

UniProt

Q96BW1

neXtProt

NX_Q96BW1

Human splice variants
Mouse splice variants