ABL1

gene product
ABL, c-ABL, JTK7, p150
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
29 antibodies
Biorbyt
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GeneTex
20 antibodies
Abnova Corporation
22 antibodies
Novus Biologicals
14 antibodies
Bethyl Laboratories
3 antibodies
antibodies-online
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OriGene
42 antibodies
Abgent
14 antibodies
Acris Antibodies GmbH
50 antibodies
NovoPro Bioscience Inc.
12 antibodies
Affinity Biosciences
11 antibodies
Aviva Systems Biology
22 antibodies
NSJ Bioreagents
6 antibodies
Atlas Antibodies
3 antibodies
LifeSpan BioSciences, Inc.
216 antibodies