EWSR1

gene product
EWS
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
505 antibodies from 37 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
4 antibodies
antibodies-online
182 antibodies
Atlas Antibodies
2 antibodies
Novus Biologicals
25 antibodies
Bethyl Laboratories
4 antibodies
OriGene
8 antibodies
Biorbyt
28 antibodies
LifeSpan BioSciences, Inc.
73 antibodies
Abgent
8 antibodies
Acris Antibodies GmbH
4 antibodies
Abnova Corporation
6 antibodies
NSJ Bioreagents
2 antibodies
Invitrogen Antibodies
6 antibodies
Boster Biological Technology
2 antibodies
Bioworld Technology, Inc
2 antibodies
Affinity Biosciences
1 antibody
Everest Biotech
1 antibody
Aviva Systems Biology
8 antibodies
Arigo
1 antibody
Santa Cruz Biotechnology
1 antibody
ProSci
6 antibodies
St John's Laboratory
6 antibodies
Antibodies.com
2 antibodies
NovoPro Bioscience Inc.
2 antibodies
Cell Signaling Technology, Inc
1 antibody
PhosphoSolutions
1 antibody
RabMAbs
4 antibodies
Proteintech Group
1 antibody
Creative Biolabs
12 antibodies
MyBioSource
11 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Abiocode, Inc.
3 antibodies
Creative Diagnostics
5 antibodies
RayBiotech, Inc.
2 antibodies
United States Biological
60 antibodies
Sigma-Aldrich
8 antibodies