DFFB

gene product
CAD, CPAN, DFF-40, DFF40
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
521 antibodies from 35 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
48 antibodies
antibodies-online
151 antibodies
Biorbyt
17 antibodies
GeneTex
9 antibodies
Abnova Corporation
13 antibodies
OriGene
10 antibodies
Invitrogen Antibodies
9 antibodies
LifeSpan BioSciences, Inc.
113 antibodies
Acris Antibodies GmbH
16 antibodies
Abgent
10 antibodies
Arigo
4 antibodies
R&D Systems
1 antibody
Rockland Immunochemicals, Inc.
5 antibodies
Enzo Life Sciences
2 antibodies
ProSci
5 antibodies
ABEOMICS Inc.
2 antibodies
Aviva Systems Biology
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
MyBioSource
10 antibodies
Abbiotec
4 antibodies
Creative Biolabs
8 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
1 antibody
Santa Cruz Biotechnology
1 antibody
United States Biological
17 antibodies
Leading Biology
11 antibodies
Boster Biological Technology
2 antibodies
Creative Diagnostics
4 antibodies
St John's Laboratory
2 antibodies
RayBiotech, Inc.
2 antibodies
Sigma-Aldrich
2 antibodies
GenWay
7 antibodies
Abbexa
1 antibody
EMD Millipore
1 antibody