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Cell line expression
Protein structure
CDC27
Cell division cycle 27ANAPC3, APC3, D0S1430E, D17S978E, NUC2
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
Top validated antibodies |
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| Invitrogen Antibodies |  10918-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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| Proteintech Group | 10918-1-AP |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| GeneTex | GTX10538 |
1 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| NSJ Bioreagents | RQ6123 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Boster Biological Technology | A03905-3 |
Polyclonal |
WB
EL
ICC
IHC
FC
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