NFATC3

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Description

Nuclear factor of activated T cells 3

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

16 (68084751 - 68229259)

Ensembl ID

ENSG00000072736  (ver. 103.38)

Orthologs

Mouse Nfatc3: ENSMUSG00000031902

UniProt

Q12968

neXtProt

NX_Q12968

Human splice variants
Mouse splice variants

Protein structure