MYLK

gene product
MLCK, MLCK1, MYLK1, smMLCK
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
338 antibodies from 33 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
7 antibodies
Abnova Corporation
7 antibodies
Proteintech Group
1 antibody
Boster Biological Technology
2 antibodies
Atlas Antibodies
2 antibodies
antibodies-online
123 antibodies
NovoPro Bioscience Inc.
3 antibodies
NSJ Bioreagents
4 antibodies
LifeSpan BioSciences, Inc.
58 antibodies
Biorbyt
21 antibodies
OriGene
5 antibodies
Abgent
3 antibodies
GeneTex
3 antibodies
Acris Antibodies GmbH
3 antibodies
Invitrogen Antibodies
4 antibodies
Affinity Biosciences
4 antibodies
FabGennix
3 antibodies
RabMAbs
2 antibodies
St John's Laboratory
6 antibodies
ProSci
2 antibodies
Antibodies.com
1 antibody
Aviva Systems Biology
3 antibodies
Everest Biotech
1 antibody
MyBioSource
9 antibodies
Creative Biolabs
9 antibodies
Bioworld Technology, Inc
1 antibody
Santa Cruz Biotechnology
1 antibody
Abbkine Scientific Co.Ltd.
4 antibodies
United States Biological
25 antibodies
Abbexa
3 antibodies
Sigma-Aldrich
2 antibodies
Creative Diagnostics
1 antibody