XPO1

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

Description

Exportin 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear membrane, Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

2:p15 (61476032 - 61538741)

Ensembl ID

ENSG00000082898  (ver. 103.38)

Orthologs

Mouse Xpo1: ENSMUSG00000020290

UniProt

O14980

neXtProt

NX_O14980

Human splice variants
Mouse splice variants