HGF

gene product
DFNB39, F-TCF, HGFB, HPTA, SF
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
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Arigo
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Enzo Life Sciences
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Boster Biological Technology
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ProSci
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Bioworld Technology, Inc
1 antibody
NovoPro Bioscience Inc.
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St John's Laboratory
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Cell Signaling Technology, Inc
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RabMAbs
1 antibody
Creative Diagnostics
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GenWay
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Sino Biological Inc.
8 antibodies
Abbkine Scientific Co.Ltd.
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BioLegend
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United States Biological
60 antibodies