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Protein structure
CYTH2
Cytohesin 2ARNO, CTS18.1, cytohesin-2, PSCD2, PSCD2L, Sec7p-L, Sec7p-like
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Top validated antibodies |
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| Proteintech Group |  10405-1-AP |
2 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | H00009266-M02 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| Abnova Corporation | H00009266-M02 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | 10405-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
|
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| antibodies-online | ABIN564002 |
1 references | Monoclonal |
WB
EL
ICC
IHC
|
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