H2AZ1

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]

Description

H2A.Z variant histone 1

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins

Chromosome

4 (99948086 - 99950355)

Ensembl ID

ENSG00000164032  (ver. 103.38)

Orthologs

Mouse H2az1: ENSMUSG00000037894

UniProt

P0C0S5

neXtProt

NX_P0C0S5

Human splice variants
Mouse splice variants

Protein structure