CDK5

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Description

Cyclin dependent kinase 5

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Plasma membrane, Cell Junctions

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (151053815 - 151057897)

Ensembl ID

ENSG00000164885  (ver. 103.38)

Orthologs

Mouse Cdk5: ENSMUSG00000028969

UniProt

Q00535

neXtProt

NX_Q00535

Human splice variants
Mouse splice variants

Protein structure