DMD

gene product
BMD, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85
The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
372 antibodies from 33 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
GeneTex
10 antibodies
Invitrogen Antibodies
8 antibodies
NovoPro Bioscience Inc.
3 antibodies
Novus Biologicals
10 antibodies
antibodies-online
89 antibodies
LifeSpan BioSciences, Inc.
78 antibodies
Abnova Corporation
10 antibodies
Arigo
5 antibodies
OriGene
8 antibodies
Acris Antibodies GmbH
13 antibodies
Atlas Antibodies
2 antibodies
NSJ Bioreagents
2 antibodies
Proteintech Group
1 antibody
Spring Bioscience
8 antibodies
Boster Biological Technology
3 antibodies
St John's Laboratory
2 antibodies
Affinity Biosciences
1 antibody
GenWay
7 antibodies
Creative Diagnostics
14 antibodies
Biorbyt
7 antibodies
Creative Biolabs
5 antibodies
United States Biological
49 antibodies
RayBiotech, Inc.
4 antibodies
Abbiotec
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
MyBioSource
7 antibodies
Sigma-Aldrich
4 antibodies
EMD Millipore
3 antibodies
Aviva Systems Biology
1 antibody
Abgent
2 antibodies
RabMAbs
1 antibody