Tissue expression
Cell line expression

AAK1

gene product
DKFZp686K16132, KIAA1048 
This gene encodes a member of the SNF1 subfamily of serine/threonine protein kinases. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. The encoded protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. This kinase has been shown to play an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating infection. Inhibitors of this kinase are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Aug 2020]
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361 antibodies from 38 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
116 antibodies
Novus Biologicals
8 antibodies
LifeSpan BioSciences, Inc.
52 antibodies
Abnova Corporation
7 antibodies
Cusabio Biotech Co., Ltd
7 antibodies
Boster Biological Technology
3 antibodies
Acris Antibodies GmbH
11 antibodies
Biorbyt
24 antibodies
OriGene
10 antibodies
GeneTex
6 antibodies
Invitrogen Antibodies
7 antibodies
Affinity Biosciences
2 antibodies
NovoPro Bioscience Inc.
4 antibodies
NSJ Bioreagents
2 antibodies
Atlas Antibodies
2 antibodies
Aviva Systems Biology
7 antibodies
R&D Systems
1 antibody
Rockland Immunochemicals, Inc.
2 antibodies
Bethyl Laboratories
2 antibodies
Cell Signaling Technology, Inc
2 antibodies
ProSci
4 antibodies
Abgent
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Antibodies.com
1 antibody
Everest Biotech
1 antibody
Abbexa
7 antibodies
RabMAbs
2 antibodies
Arigo
1 antibody
St John's Laboratory
2 antibodies
MyBioSource
6 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
Leading Biology
5 antibodies
Abbiotec
2 antibodies
United States Biological
19 antibodies
Creative Diagnostics
6 antibodies
RayBiotech, Inc.
2 antibodies
Creative Biolabs
4 antibodies