Tissue expression
Cell line expression
Protein structure

IFIH1

Interferon induced with helicase C domain 1
Hlcd, IDDM19, MDA-5, MDA5 
IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome [provided by RefSeq, Jul 2020]
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545 antibodies from 42 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
27 antibodies
Proteintech Group
4 antibodies
antibodies-online
150 antibodies
Novus Biologicals
30 antibodies
GeneTex
7 antibodies
Abnova Corporation
10 antibodies
Acris Antibodies GmbH
9 antibodies
Boster Biological Technology
4 antibodies
Everest Biotech
1 antibody
Biorbyt
53 antibodies
OriGene
23 antibodies
Affinity Biosciences
2 antibodies
Arigo
2 antibodies
St John's Laboratory
5 antibodies
Enzo Life Sciences
6 antibodies
Bioworld Technology, Inc
1 antibody
Cusabio Biotech Co., Ltd
9 antibodies
ProSci
6 antibodies
Abgent
5 antibodies
Antibodies.com
1 antibody
NovoPro Bioscience Inc.
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
Aviva Systems Biology
4 antibodies
Atlas Antibodies
1 antibody
Cell Signaling Technology, Inc
1 antibody
NSJ Bioreagents
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
MyBioSource
8 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
RabMAbs
2 antibodies
United States Biological
45 antibodies
Leading Biology
5 antibodies
Abbexa
11 antibodies
Abbiotec
2 antibodies
Creative Biolabs
17 antibodies
EMD Millipore
2 antibodies
Abiocode, Inc.
1 antibody
Creative Diagnostics
7 antibodies
RayBiotech, Inc.
3 antibodies
GenWay
2 antibodies
Rockland Immunochemicals, Inc.
2 antibodies