Tissue expression
Cell line expression
Protein structure
RUNX3
RUNX family transcription factor 3AML2, CBFA3, PEBP2A3
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Top validated antibodies |
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antibodies-online | ![]() |
1 references | Monoclonal |
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GeneTex | ![]() |
Monoclonal |
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Invitrogen Antibodies | ![]() |
Monoclonal |
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Novus Biologicals | ![]() |
Monoclonal |
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LSBio | ![]() |
Monoclonal |
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