FGF1

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

Description

Fibroblast growth factor 1

Tissue specificity

Tissue enhanced (brain, choroid plexus)

Subcell location

Nucleoplasm

Predicted location

Intracellular, Secreted in other tissues

Protein family

Cancer-related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

5:q31.3 (142592178 - 142698070)

Ensembl ID

ENSG00000113578  (ver. 103.38)

Orthologs

Mouse Fgf1: ENSMUSG00000036585

UniProt

P05230

neXtProt

NX_P05230

Human splice variants
Mouse splice variants