LAMC1

gene product
LAMB2
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
471 antibodies from 31 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Atlas Antibodies
6 antibodies
Novus Biologicals
34 antibodies
antibodies-online
177 antibodies
R&D Systems
1 antibody
NSJ Bioreagents
5 antibodies
Bioworld Technology, Inc
1 antibody
LifeSpan BioSciences, Inc.
110 antibodies
Acris Antibodies GmbH
6 antibodies
Affinity Biosciences
1 antibody
OriGene
7 antibodies
Biorbyt
23 antibodies
Invitrogen Antibodies
2 antibodies
Abnova Corporation
13 antibodies
Santa Cruz Biotechnology
1 antibody
Boster Biological Technology
2 antibodies
NovoPro Bioscience Inc.
5 antibodies
GeneTex
5 antibodies
Abgent
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Cell Signaling Technology, Inc
1 antibody
Aviva Systems Biology
3 antibodies
Creative Biolabs
9 antibodies
Creative Diagnostics
7 antibodies
MyBioSource
9 antibodies
EMD Millipore
2 antibodies
United States Biological
25 antibodies
Abiocode, Inc.
1 antibody
St John's Laboratory
1 antibody
Abbexa
3 antibodies
Sigma-Aldrich
5 antibodies
RabMAbs
1 antibody