Tissue expression
Cell line expression
Protein structure
GPI
Glucose-6-phosphate isomeraseAMF, NLK
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Top validated antibodies |
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Atlas Antibodies | HPA024305 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
Proteintech Group | 15171-1-AP | 20 references | Polyclonal |
WB
EL
ICC
IHC |
|
NSJ Bioreagents | V7817 | Monoclonal |
WB
ICC
IHC
PA
OA
|
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Invitrogen Antibodies | 15171-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
||
Novus Biologicals | NBP1-47523 | 2 references | Monoclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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