TOP2A

gene product
TOP2
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
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862 antibodies from 38 providers.

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AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
52 antibodies
Abnova Corporation
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Atlas Antibodies
2 antibodies
antibodies-online
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Acris Antibodies GmbH
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OriGene
218 antibodies
NovoPro Bioscience Inc.
3 antibodies
Proteintech Group
2 antibodies
LifeSpan BioSciences, Inc.
156 antibodies
Invitrogen Antibodies
11 antibodies
Boster Biological Technology
5 antibodies
Enzo Life Sciences
3 antibodies
Cell Signaling Technology, Inc
4 antibodies
Aviva Systems Biology
10 antibodies
Abgent
10 antibodies
GeneTex
8 antibodies
Affinity Biosciences
5 antibodies
NSJ Bioreagents
5 antibodies
Bioworld Technology, Inc
2 antibodies
St John's Laboratory
9 antibodies
ProSci
6 antibodies
Bethyl Laboratories
2 antibodies
R&D Systems
1 antibody
Abbkine Scientific Co.Ltd.
8 antibodies
RabMAbs
7 antibodies
FabGennix
3 antibodies
MyBioSource
13 antibodies
RayBiotech, Inc.
3 antibodies
United States Biological
78 antibodies