Tissue expression
Cell line expression
Protein structure

TOP2A

DNA topoisomerase II alpha
TOP2 
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
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1782 antibodies from 45 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
3 antibodies
Atlas Antibodies
2 antibodies
Novus Biologicals
90 antibodies
Abnova Corporation
12 antibodies
Invitrogen Antibodies
130 antibodies
Acris Antibodies GmbH
16 antibodies
antibodies-online
475 antibodies
OriGene
243 antibodies
Biorbyt
283 antibodies
NovoPro Bioscience Inc.
3 antibodies
FineTest Biotech
2 antibodies
GeneTex
9 antibodies
Enzo Life Sciences
3 antibodies
Cell Signaling Technology, Inc
4 antibodies
Boster Biological Technology
8 antibodies
Aviva Systems Biology
10 antibodies
Cusabio Biotech Co., Ltd
15 antibodies
Affinity Biosciences
5 antibodies
Abgent
10 antibodies
NSJ Bioreagents
12 antibodies
HUABIO Research
3 antibodies
St John's Laboratory
17 antibodies
Bioworld Technology, Inc
2 antibodies
ProSci
6 antibodies
Bethyl Laboratories
2 antibodies
ABEOMICS Inc.
4 antibodies
R&D Systems
1 antibody
BioLegend
2 antibodies
Abbkine Scientific Co.Ltd.
8 antibodies
RabMAbs
7 antibodies
Creative Biolabs
34 antibodies
Creative Diagnostics
10 antibodies
FabGennix
3 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
Abbexa
21 antibodies
MyBioSource
13 antibodies
RayBiotech, Inc.
3 antibodies
United States Biological
78 antibodies
Leading Biology
6 antibodies
EMD Millipore
2 antibodies
Abbiotec
1 antibody
Arigo
1 antibody
MS Validated Antibodies GmbH
1 antibody