HSD17B1

gene product
EDH17B2, EDHB17, HSD17, MGC138140, SDR28C1
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
293 antibodies from 32 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Abnova Corporation
3 antibodies
Novus Biologicals
7 antibodies
antibodies-online
105 antibodies
LifeSpan BioSciences, Inc.
42 antibodies
Proteintech Group
2 antibodies
Biorbyt
20 antibodies
NSJ Bioreagents
3 antibodies
Invitrogen Antibodies
4 antibodies
GeneTex
3 antibodies
Abgent
4 antibodies
NovoPro Bioscience Inc.
2 antibodies
Boster Biological Technology
1 antibody
OriGene
3 antibodies
Atlas Antibodies
2 antibodies
Aviva Systems Biology
2 antibodies
R&D Systems
2 antibodies
RabMAbs
4 antibodies
ProSci
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Affinity Biosciences
1 antibody
Creative Biolabs
5 antibodies
Creative Diagnostics
7 antibodies
Acris Antibodies GmbH
3 antibodies
Abbexa
9 antibodies
MyBioSource
2 antibodies
St John's Laboratory
2 antibodies
United States Biological
16 antibodies
Leading Biology
4 antibodies
Sigma-Aldrich
3 antibodies
RayBiotech, Inc.
1 antibody
GenWay
1 antibody