CASP10

gene product
MCH4
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
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Antibodies

 

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Antibodypedia Validation Initiative

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545 antibodies from 41 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
207 antibodies
Novus Biologicals
13 antibodies
Boster Biological Technology
3 antibodies
NovoPro Bioscience Inc.
1 antibody
Proteintech Group
1 antibody
Biorbyt
31 antibodies
Acris Antibodies GmbH
18 antibodies
Aviva Systems Biology
4 antibodies
GeneTex
8 antibodies
Abgent
8 antibodies
Affinity Biosciences
2 antibodies
Abnova Corporation
10 antibodies
OriGene
12 antibodies
Invitrogen Antibodies
8 antibodies
Bioworld Technology, Inc
3 antibodies
LifeSpan BioSciences, Inc.
70 antibodies
R&D Systems
3 antibodies
NSJ Bioreagents
2 antibodies
RabMAbs
2 antibodies
Enzo Life Sciences
1 antibody
St John's Laboratory
4 antibodies
Creative Biolabs
5 antibodies
Arigo
4 antibodies
MyBioSource
11 antibodies
Creative Diagnostics
6 antibodies
Abbiotec
2 antibodies
RayBiotech, Inc.
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Atlas Antibodies
1 antibody
BioLegend
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
United States Biological
67 antibodies
Spring Bioscience
4 antibodies
GenWay
5 antibodies
Abiocode, Inc.
1 antibody
ProSci
1 antibody
Sigma-Aldrich
4 antibodies
EMD Millipore
2 antibodies
Abbexa
3 antibodies
Exalpha Biologicals, Inc.
1 antibody