CASP10

gene product
MCH4
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
463 antibodies from 41 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
13 antibodies
Boster Biological Technology
3 antibodies
NovoPro Bioscience Inc.
1 antibody
antibodies-online
141 antibodies
Proteintech Group
1 antibody
Biorbyt
23 antibodies
Acris Antibodies GmbH
18 antibodies
Aviva Systems Biology
4 antibodies
GeneTex
8 antibodies
LifeSpan BioSciences, Inc.
61 antibodies
Abgent
8 antibodies
Affinity Biosciences
2 antibodies
Abnova Corporation
10 antibodies
OriGene
13 antibodies
Invitrogen Antibodies
8 antibodies
Bioworld Technology, Inc
3 antibodies
R&D Systems
3 antibodies
NSJ Bioreagents
2 antibodies
RabMAbs
2 antibodies
Enzo Life Sciences
1 antibody
St John's Laboratory
4 antibodies
Creative Biolabs
5 antibodies
Arigo
4 antibodies
MyBioSource
11 antibodies
Creative Diagnostics
6 antibodies
Abbiotec
2 antibodies
RayBiotech, Inc.
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Atlas Antibodies
1 antibody
BioLegend
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
United States Biological
67 antibodies
Spring Bioscience
4 antibodies
GenWay
5 antibodies
Abiocode, Inc.
1 antibody
ProSci
1 antibody
Sigma-Aldrich
4 antibodies
EMD Millipore
2 antibodies
Abbexa
3 antibodies
Exalpha Biologicals, Inc.
1 antibody