Tissue expression
Cell line expression
Protein structure
TP53BP1
Tumor protein p53 binding protein 153BP1, p202, TDRD30
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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Novus Biologicals | NB100-304 | 422 references | Polyclonal |
WB
ICC
IP
IHC
FC
ChIP |
|
Invitrogen Antibodies | PA1-16565 | 2 references | Polyclonal |
WB
ICC
IP
IHC
FC
ChIP
OA
|
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antibodies-online | ABIN151770 | 287 references | Polyclonal |
WB
ICC
IP
IHC
FC
ChIP |
|
GeneTex | GTX102595 | 2 references | Polyclonal |
WB
ICC
IHC
|
|
LSBio | LS-C313109 | Polyclonal |
WB
ICC
IHC
|
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Supportive data in Antibodypedia
Data presented on provider website
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Recommended by provider